Folate:B12
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
131.619724
|
1
|
<0.0001
|
***
|
|
folate_B12
|
2.967510
|
1
|
0.08
|
ns
|
|
Study
|
1.329267
|
1
|
0.2
|
ns
|
|
GA_samp
|
131.577880
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
5.013235
|
1
|
0.03
|
*
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
32.3040552
|
1
|
<0.0001
|
***
|
|
folate_B12
|
0.1638235
|
1
|
0.7
|
ns
|
|
Study
|
9.3893442
|
1
|
0.002
|
**
|
|
GA_samp
|
1638.1363304
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
0.0023293
|
1
|
1.0
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
320.4006010
|
1
|
<0.0001
|
***
|
|
folate_B12
|
1.3497714
|
1
|
0.2
|
ns
|
|
Study
|
0.1266652
|
1
|
0.7
|
ns
|
|
GA_samp
|
807.9421439
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
0.0677801
|
1
|
0.8
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.333
|
0.333
|
0.6
|
ns
|
|
3
|
Study
|
1
|
Inf
|
9.600
|
9.600
|
0.002
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.076
|
0.076
|
0.8
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
0.120
|
0.120
|
0.7
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.406
|
0.406
|
0.5
|
ns
|
|
3
|
Study
|
1
|
Inf
|
17.721
|
17.721
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.153
|
0.153
|
0.7
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
0.217
|
0.217
|
0.6
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.412
|
0.412
|
0.5
|
ns
|
|
3
|
Study
|
1
|
Inf
|
44.737
|
44.737
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.213
|
0.213
|
0.6
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
1.231
|
1.231
|
0.3
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
13.46 (8.64, 20.98)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.09
|
|
StudySTOP
|
0.91 (0.77, 1.07)
|
0.25
|
|
GA_samp
|
1.17 (1.14, 1.20)
|
<0.0001
|
|
folate_B12:StudySTOP
|
1.00 (1.00, 1.00)
|
0.03
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.94 (1.55, 2.43)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.49
|
|
StudySTOP
|
1.14 (1.07, 1.23)
|
0.0002
|
|
GA_samp
|
1.34 (1.32, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.06 (0.05, 0.08)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.13
|
|
StudySTOP
|
1.03 (0.94, 1.13)
|
0.52
|
|
GA_samp
|
1.32 (1.29, 1.34)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
15.64 (8.87, 27.58)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.60
|
|
StudySTOP
|
0.71 (0.59, 0.86)
|
0.0003
|
|
GA_samp
|
0.99 (0.96, 1.03)
|
0.79
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
3.91 (2.16, 7.07)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.58
|
|
StudySTOP
|
0.62 (0.51, 0.75)
|
<0.0001
|
|
GA_samp
|
0.99 (0.96, 1.03)
|
0.70
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.53 (4.96, 6.16)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.57
|
|
StudySTOP
|
0.87 (0.84, 0.90)
|
<0.0001
|
|
GA_samp
|
1.00 (0.99, 1.01)
|
0.61
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:B12 ratio and may be misleading when interaction term is involved.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
95.45434
|
7.888834
|
102.11034
|
81.02226
|
112.4571
|
|
STOP
|
97.32665
|
7.521490
|
78.50036
|
83.44885
|
113.5124
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
89.70666
|
2.645779
|
184.2667
|
84.63571
|
95.08143
|
|
STOP
|
102.63004
|
2.675395
|
112.7167
|
97.46401
|
108.06989
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.271708
|
0.0755750
|
406.0961
|
2.127895
|
2.425241
|
|
STOP
|
2.342068
|
0.0633228
|
205.9442
|
2.220493
|
2.470299
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
14.41229
|
0.9070753
|
Inf
|
12.739738
|
16.30443
|
|
STOP
|
10.28088
|
0.4603074
|
Inf
|
9.417142
|
11.22383
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.481303
|
0.2322185
|
Inf
|
3.05466
|
3.967535
|
|
STOP
|
2.146647
|
0.1004986
|
Inf
|
1.95844
|
2.352940
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.423639
|
0.0673084
|
Inf
|
5.293309
|
5.557179
|
|
STOP
|
4.717079
|
0.0405035
|
Inf
|
4.638358
|
4.797136
|
Comparisons
Effect for every 100 unit increase in Folate:B12 ratio.
|
Hormone
|
Contrast
|
Study
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
folate_B12247.58 / folate_B12147.58
|
SCOPE
|
0.96 (0.93, 1.01)
|
0.09
|
|
PRL (ng/ml)
|
folate_B12247.58 / folate_B12147.58
|
STOP
|
1.02 (0.99, 1.06)
|
0.2
|
|
hPL (μg/ml)
|
folate_B12247.58 / folate_B12147.58
|
SCOPE
|
1.00 (0.98, 1.01)
|
0.5
|
|
hPL (μg/ml)
|
folate_B12247.58 / folate_B12147.58
|
STOP
|
1.00 (0.98, 1.01)
|
0.5
|
|
GH2 (ng/ml)
|
folate_B12247.58 / folate_B12147.58
|
SCOPE
|
0.99 (0.97, 1.00)
|
0.1
|
|
GH2 (ng/ml)
|
folate_B12247.58 / folate_B12147.58
|
STOP
|
0.99 (0.97, 1.00)
|
0.1
|
|
Insulin (uU/ml)
|
folate_B12247.58 / folate_B12147.58
|
SCOPE
|
0.99 (0.96, 1.02)
|
0.6
|
|
Insulin (uU/ml)
|
folate_B12247.58 / folate_B12147.58
|
STOP
|
0.99 (0.96, 1.02)
|
0.6
|
|
HOMA-IR
|
folate_B12247.58 / folate_B12147.58
|
SCOPE
|
0.99 (0.96, 1.02)
|
0.6
|
|
HOMA-IR
|
folate_B12247.58 / folate_B12147.58
|
STOP
|
0.99 (0.96, 1.02)
|
0.6
|
|
Glucose (mmol/L)
|
folate_B12247.58 / folate_B12147.58
|
SCOPE
|
1.00 (0.99, 1.01)
|
0.6
|
|
Glucose (mmol/L)
|
folate_B12247.58 / folate_B12147.58
|
STOP
|
1.00 (0.99, 1.01)
|
0.6
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
